Research Directory Details | National Medical Research Register

Female breast cancer in a multi-ethnic Malaysian setting

Multicentre clinical epidemiological study of female breast cancer in a multi-ethnic Malaysian setting (Epi-Can)

Epi-Can

General Information
Research Type
Observational
Description
All patients who are newly diagnosed with stage I to stage IV breast cancer from year 2017 till 2021 aged 18 years and above will be included.
A multicentre retrospective cohort study will be conducted in 6 of the Ministry of Health hospitals in Malaysia and coordinated by Institute for Clinical Research. Medical record of patients with newly diagnosed breast cancer from participating clinical sites who meet eligibility criteria will be reviewed. This project will be a collaboration between ICR and MOH hospitals. The results of this study will aid to observe secular changes as well as long term outcomes for breast cancer patients in real world clinical practice.
This study aimed to understand the nature of breast cancer patients’ presentation, diagnosis, treatment, treatment induced cardiovascular complications and survival. The specific objectives are;
1. To describe the characteristics of patients with breast cancer and management of the disease
2. To identify independent prognostic factors for breast cancer survival
3. To assess the following survival measures among breast cancer patients:
a) Overall survival (OS)
b) Relative survival (RS)
c) Disease Free Survival (DFS)
d) Cause Specific Survival (CSS)
4. To assess cancer therapy related cardiac complication
The expected study outcomes are to evaluate their overall survival, disease-free survival, breast cancer cause-specific mortality and relative survival while describing the variation across age, socioeconomic, geographic regions, ethnic differences and its trend over time in Malaysia.
A minimum of 6130 breast cancer patients are required to answer the study objectives
The duration taken for this study would include field training and data collection is 2 years. The data analysis and reporting are expected to take 6 months. This study is expected to be completed by December 2024.
Study Information
RMK Priority Area
Non-Communicable Disease
Research Level
Clinical Practice
Research Keyword
breast cancer, survival, cardiac complication, prognostic factor
Inclusion & Exclusion Criteria
Inclusion Criteria
Malaysian aged 18 years and above |Newly diagnosed with breast cancer at any stages between year 2017 to 2021
Exclusion Criteria
Ductal carcinoma in situ |Male breast cancer
Study Timeline
Expected / Actual Date Study Starts - First Enrolment of subject / Collecting data
Oct, 03 2022
Expected / Actual Date Study Completed
Dec, 31 2024
Expected / Actual Duration of Study Enrollment / Data Collection
117 weeks